Info For Your

Information About Thalassemia

Blood Diseases
Cushing Syndrome
Myelodysplastic syndrome
Septic Shock
Sickle Cell Anemia
Wegener Granulomatoisis
Thalassemia (American English) (or Thalassaemia in British English) is an inherited disease of the red blood cells, classified as a hemoglobinopathy. The genetic defect results in synthesis of an abnormal hemoglobin molecule. The blood cells are vulnerable to mechanical injury and die easily. To survive, many people with thalassaemia need blood transfusions at regular intervals.

Being a carrier of the disease confers a degree of protection against malaria, and is quite common among people from Italian or Greek origin, since malaria was widespread in those countries at one time. In that respect it resembles another genetic disorder, sickle-cell disease

The thalassemias are classified according to which chain of the globin molecule is affected: in a thalassemia, the production of a globin is deficient, while in Y thalassemia the production of Y globin is defective. Thalassemia produces a deficiency of a or Y globin, unlike sickle-cell disease which produces a specific mutant form of Y globin.

Both a and Y thalassemia are inherited in an autosomal recessive fashion. Both parents must be carriers in order for a child to be affected. If both parents carry a hemoglobinopathy trait, there is a 25% chance with each pregnancy for an affected child. Genetic counseling and genetic testing is recommended for families that carry a thalassemia trait.

This article is from Wikipedia. All text is available under the terms of the GNU Free Documentation License
View live article
© 2005 Info For Your Health. All rights reserved.