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Information About Angioedema Therapy

Anaphylaxis symptoms
Angioedema Pathophysiology
Angioedema Therapy
  Angioedema Therapy
In allergic angioedema, avoidance of the allergen and use of antihistamines may prevent future attacks. Cetirizine, marketed as Zyrtec, is a commonly prescribed antihistamine for angioedema. Severe angioedema cases may require desensitization to the putative allergen, as mortality can occur. Chronic cases require steroid therapy, which generally leads to a good response.

In ACE inhibitor use, the medication needs to be discontinued, and all similar drugs need to be avoided. There is a certain degree of controversy whether angiotensin II receptor antagonists are safe in patients with a previous attack of angioedema.

In hereditary angioedema, specific stimuli that have previously luxated attacks may need to be avoided in the future. Severe cases receive replacement therapy with purified vapor-heated C1-esterase inhibitor (as described by Waytes et al 1996), while danazol (an androgen) relieves symptoms somewhat. In the absence of C1inh concentrate, fresh frozen plasma is used. DX-88 is an inhibitor of kallikrein that is due to be marketed as an orphan drug for hereditary angioedema.

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