Toxic headaches can also be caused by exposure to toxic chemicals, including lead, insecticides, organophosphate pesticides, chemical solvents, alcohol (a hangover), carbon tetrachloride, and some household cleaners. This often happens through destabilizing the magnesium metabolism of the cell, which triggers a cascade of biological and neurological reactions, culminating in a migraine, toxic headache, or worse (such as neurological damage).

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