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Information About Stevens-Johnson Syndrome

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  Stevens-Johnson Syndrome
 
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis are moderate and severe variations of the same adverse drug reaction. The reactions associated with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis can also be the result of mycoplasma pneumonia. The reaction is identified by blistering and sloughing of skin and mucosal membranes. Stevens-Johnson Syndrome also carries with it seemingly unstoppable acute pain, which often lasts for several weeks. SJS and TEN are very challenging to treat. Even after treating the condition with round-the-clock application of lubricant ointments, antibiotics drops, and steroid drops the majority of patients still end up with a lifetime of ocular problems. The residual symptoms of Stevens-Johnson Syndrome include the following:

  • mild dry eye
  • ongoing inflammation
  • scarred eyelids
  • entropion with trichiasis
  • photophobia
  • decreased vision
  • chronic corneal ulcers
  • corneal vascularization
  • total limbal deficiency
  • complete loss of tears
  • significant vision loss
  • blindness
  • constant severe pain
  • complete loss of one or both eyes
One of the treatments that is presently being used to stop the SJSocular reaction involves the application of amniotic membrane to all eye and inner eyelid surfaces as soon as possible (before the 14 th day of the acute phase of Stevens-Johnson Syndrome). Due to its anti-inflammatory and growth factors of amniotic membrane transplantation in most cases is a successful treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
 
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