Gastroenteritis , or inflammation of the gastrointestinal tract, is an illness of fever, diarrhea and vomiting caused by an infectious virus, bacterium or parasite. It usually is of acute onset, normally lasting less than 10 days and self-limiting. Sometimes it is referred to simply as 'gastro'. It is often called the stomach flu or gastric flu even though it is not related to influenza.
If the inflammation is limited to the stomach, the term gastritis is used, and if the small bowel alone is affected it is enteritis.
Gastritis is a medical term for inflammation of the lining of the stomach. It means that white blood cells move into the wall of the stomach as a response to some type of injury. Gastritis does not mean that there is a peptic ulcer or cancer. It is simply inflammation — either acute or chronic. Gastritis has many underlying causes, from infection with the bacterium H. pylori, bile reflux, or excessive consumption of alcohol or certain foods or drugs like aspirin..
Gastritis can be healed by using medicines that reduce stomach acid, avoiding some foods, alcohol and medicine.
The most common viral causes of acute gastroenteritis (AGE) in children <5 years of age in both developed countries as well as developing countries are rotavirus group A (up to 50% of the cases), noroviruses (the most common cause of outbreaks of AGE in all age groups), adenoviruses type 40 and 41, astrovirus, and sapovirus.
This is less common in developed countries. Campylobacter jejuni is responsible for 5-10% of cases, whereas Salmonella species, Shigella species, and various pathogenic types of Escherichia coli account for a small percentage.
In the developing world enterotoxigenic, enteropathogenic and enteroinvasive E. coli are important due to the sheer number of cases, whereas Shigella causes debilitating illness and has increasing resistance against cheap and readily available antibiotics. Cholera, caused by Vibrio cholerae is another important cause of acute diarrhoeal illness and subsequent death in the developing world.
Outbreaks of Giardia lamblia can cause dehydrating diarrhoea in infants, and Cryptosporidium is known to cause 1-4% of cases of acute diarrhoea in hospitalised infants.
Globally, diarrhea caused 4.6 million deaths in children in 1980 alone, most of these in the developing world. This number has now come down significantly to approximately 1.5 million deaths annually, largely due to global introduction of proper oral rehydration therapy (Victora et al 2000).
The incidence in the developed countries is as high as 1-2.5 cases per child per year and a major cause of hospitalisation in this age group.
The main symptoms include poor feeding in infants, vomiting and fever, usually rapidly followed by diarrhoea. Viral diarrhoea usually causes frequent watery stools, whereas blood stained diarrhoea may be indicative of bacterial colitis.
The child with gastroenteritis may be lethargic and have signs of dehydration, dry mucous membranes, tachycardia, reduced skin turgor, sunken fontanelles and sunken eye balls, poor perfusion and ultimately shock.
It is important to consider infectious gastroenteritis as a diagnosis of exclusion. A few loose stools and vomiting may be the result of systemic infection such as pneumonia, septicaemia, urinary tract infection and even meningitis. Surgical conditions like appendicitis, intussusception and, rarely, even Hirschsprung's disease may mislead the clinician.
The main treatment of diarrhoeal illness in both children and adults is rehydration, i.e. replenishment of water lost in the stools. Depending on the degree of dehydration, this can be done orally with commercial or home-made rehydration fluids, or through intravenous delivery. Symptoms may exhibit themselves for up to 6 days. Bowel movements will return to normal within a week after that.
Because of the stomach's swollen fragilility due to the disease, rehydration through the drinking of fluids must be slow and spaced out as to not overwhelm the stomach and cause further nausea and vomiting. Doctors recommend that one take slow sips every few minutes, and if vomiting still occurs, it's best to refrain from any drinking or eating for the next half hour.
Loperamide is an opioid analogue commonly used for symptomatic treatment of diarrhoea. It slows down gut motility, but does not cross the mature blood-brain barrier to cause the central nervous effect of other opioids. In too high doses, loperamide may cause constipation and significant slowing down of passage of faeces, but an appropriate single dose will not slow down the duration of the disease (Wingate et al, 2001).
Loperamide is not recommended in children, especially in children younger than 2 years of age, as it may cause systemic toxicity due to an immature blood brain barrier, and oral rehydration therapy remains the main stay treatment for children.
Antibiotics are of little or no use, unless persistent symptomatic colonisation (as seen in Giardia lamblia infestations) or septicaemia is present.
Dehydration is the most concerning complication of the diarrhoea caused by gastroenteritis and needs prompt rectification by a clinician if severe.
Febrile convulsions are not uncommon in children, especially with rotavirus infections.
Sugar malabsorption is the most common complication, especially in infants. This may result in reappearance of diarrhoea once milk, and hence the sugar lactose, is reintroduced into the diet.
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