A dental drill (or dentist's drill) is a small, high-speed drill used in dentistry to remove decayed tooth material prior to the insertion of a dental filling. Dental drills are used in the treatment of dental caries. The term "dental drill" is considered the more colloquial form of the term "dental handpiece". The latter is a more generic and euphemistic term for generic dental tools.

Modern dental drills can rotate at over 800,000 rpm, and generally use hard metal alloy bits. Dental drill bits come in a great variety of shapes designed for specific applications. They are often made of steel with a tungsten carbide coating, or of tungsten carbide entirely. The bit may also have a diamond coating.

Dental drills, which have a distinctive, shrill sound, are often a prominent factor in many people's fear of dentistry (dentophobia).